Description

Trifluoroacetic Acid CAS NO 1523572-02-2 is a potent fluorinated organic acid and versatile reagent widely used in synthetic chemistry. Its strong acidity and high volatility make it an indispensable solvent and catalyst for complex organic transformations, particularly in peptide synthesis and pharmaceutical manufacturing. This high-purity compound is essential for researchers and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-quality reagents for critical processes.

Application

• Peptide Synthesis: As a key cleavage and deprotection reagent in solid-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: As a catalyst and solvent in the synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules.
• Analytical Chemistry: As a mobile phase modifier in High-Performance Liquid Chromatography (HPLC) for separating peptides and proteins.
• Organic Synthesis: For esterification reactions, protecting group removal, and as a solvent for reactions requiring a strong, non-nucleophilic acid.
• Polymer Chemistry: In the production and modification of specialty polymers and fluoropolymers.
• Agrochemical Manufacturing: As a building block and reagent in the synthesis of advanced herbicides and pesticides.

Basic Information

Product Name	Trifluoroacetic Acid
CAS No.	1523572-02-2
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; 2,2,2-Trifluoroacetic Acid; CF3COOH; Trifluoroacetic Acid Anhydride (common misnomer); Kyselina trifluoroctova; Acide trifluoroacetique
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and corrosive nature, containers must be kept upright and securely sealed. Recommended storage temperature is 2-8°C to minimize vapor pressure and degradation.

Specification

Item	Specification
Appearance	Colorless Clear Liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (KF)	≤ 0.05%
Residue on Evaporation	≤ 0.005%
Chloride (Cl)	≤ 10 ppm
Sulfate (SO4)	≤ 10 ppm
Heavy Metals (as Pb)	≤ 5 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.