Description

6-Oxa-1-Azaspiro[3.4]Octane Hemioxalate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting complex diseases. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring spirocyclic or constrained ring systems for enhanced biological activity and metabolic stability.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and develop proprietary compound libraries.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and optimization of API synthesis routes under GMP conditions.
• Bioconjugation & Probe Synthesis: The reactive nitrogen in the azaspirane structure can be utilized for creating chemical probes, linkers, or bioconjugates for diagnostic and therapeutic applications.
• Academic & Institutional R&D: Employed in university and research institute laboratories for fundamental studies in organic synthesis and heterocyclic chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry with custom synthesis and development services.

Basic Information

Product Name	6-Oxa-1-Azaspiro[3.4]Octane Hemioxalate
CAS No.	1523571-99-4
Molecular Formula	C8H13NO5
Molecular Weight	203.19 g/mol
Synonyms	1-Azaspiro[3.4]octan-6-one, oxalate (1:?); 6-Oxa-1-azaspiro[3.4]octane oxalate salt; 1-Aza-6-oxaspiro[3.4]octane hemioxalate; Azaspiro[3.4]octane-6-one oxalate; Spiro[cyclopropane-1,2'-oxolane]-2'-one derivative; 6-Oxa-1-azaspiro[3.4]octane, oxalic acid salt; Advanced Spirocyclic Intermediate; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 6-Oxa-1-Azaspiro[3.4]Octane Hemioxalate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Specifications are designed to meet the stringent requirements of pharmaceutical R&D and can be aligned with client-specific protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.