Description

1-Cbz-1,7-Diaza-Spiro[4.5]Decane Hydrochloride is a high-purity, protected spirocyclic diamine building block used in advanced pharmaceutical research and development. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in the synthesis of novel drug candidates targeting central nervous system and other therapeutic areas. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A key chiral scaffold in the synthesis of potential bioactive molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Protease Inhibitor Development: The spirocyclic diamine core is valuable for creating inhibitors targeting various protease enzymes.
• Ligand Synthesis for Catalysis: Employed in the preparation of sophisticated ligands for asymmetric catalysis.
• Chemical Biology Probes: Serves as a building block for developing molecular probes to study biological pathways.
• Peptidomimetic Chemistry: Integral for designing and synthesizing peptidomimetics with enhanced metabolic stability.

Basic Information

Product Name	1-Cbz-1,7-Diaza-Spiro[4.5]Decane Hydrochloride
CAS No.	1523571-82-5
Molecular Formula	C16H23N3O2 • HCl
Molecular Weight	325.84 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-1,7-diazaspiro[4.5]decane hydrochloride; 1-Cbz-1,7-Diazaspiro[4.5]decane HCl; 1,7-Diaza-spiro[4.5]decane-1-carboxylic acid benzyl ester hydrochloride; N-Cbz-1,7-Diazaspiro[4.5]decane hydrochloride; Benzyl 1,7-diazaspiro[4.5]decane-1-carboxylate hydrochloride; 1,7-Diazaspiro[4.5]decane-1-carboxylic acid, phenylmethyl ester, hydrochloride (1:1); 1-Carbobenzyloxy-1,7-diazaspiro[4.5]decane hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Cbz-1,7-Diaza-Spiro[4.5]Decane Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.