Description

(3R,4S)-1-tert-Butyl 3-Ethyl 4-Hydroxypyrrolidine-1,3-Dicarboxylate is a high-purity, stereochemically defined chiral pyrrolidine derivative, serving as a critical building block in modern organic synthesis. Its value lies in providing a rigid, functionalized scaffold for constructing complex molecules with precise three-dimensional control. This advanced pharmaceutical intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Asymmetric Catalysis Ligand Precursor: Used to develop novel chiral ligands and organocatalysts for enantioselective transformations.
• Peptidomimetics & Proline Analogue Synthesis: The protected hydroxypyrrolidine core is integral for creating conformationally constrained peptide mimics and modified amino acids.
• Agrochemical Research: Employed in the design and synthesis of new, stereospecific herbicides and fungicides.
• Academic & Process Chemistry: A valuable reagent for methodological development and scale-up studies in synthetic organic chemistry laboratories.

Basic Information

Product Name	(3R,4S)-1-tert-Butyl 3-Ethyl 4-Hydroxypyrrolidine-1,3-Dicarboxylate
CAS No.	1523541-94-7
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-ethyl-4-hydroxypyrrolidine-3-carboxylate; (3R,4S)-1-Boc-3-(ethoxycarbonyl)-4-hydroxypyrrolidine; tert-Butyl (3R,4S)-3-(ethoxycarbonyl)-4-hydroxypyrrolidine-1-carboxylate; 1-Boc-3-(ethoxycarbonyl)-4-hydroxypyrrolidine; (3R,4S)-4-Hydroxy-1,3-pyrrolidinedicarboxylic acid 1-tert-butyl 3-ethyl ester; (3R,4S)-1-N-Boc-3-(ethoxycarbonyl)-4-hydroxypyrrolidine; Pyrrolidine-1,3-dicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 3-ethyl ester, (3R,4S)-
EINECS	Contact for details

Quality Control

Our (3R,4S)-1-tert-Butyl 3-Ethyl 4-Hydroxypyrrolidine-1,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.