Description

Bcn-Succinimidyl Ester CAS NO 1516551-46-4 is a high-purity, functionalized chemical reagent designed for advanced bioconjugation and labeling applications. This compound is critical for researchers and manufacturers requiring precise and stable covalent attachment of biomolecules, such as peptides, proteins, and oligonucleotides. It is an essential tool for professionals in pharmaceutical development, proteomics research, and the production of diagnostic reagents and antibody-drug conjugates (ADCs).

Application

• Bioconjugation Reagent: For the stable covalent coupling of the Bcn (Bicyclo[6.1.0]nonyne) moiety to amine-containing biomolecules like proteins and peptides.
• Click Chemistry Linker: Serves as a key intermediate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for bioorthogonal labeling.
• Proteomics Research: Used in the labeling and enrichment of target proteins for mass spectrometry analysis and cellular imaging.
• Antibody-Drug Conjugate (ADC) Synthesis: Enables the site-specific attachment of cytotoxic payloads to antibodies for targeted cancer therapies.
• Diagnostic Assay Development: Facilitates the labeling of detection probes and antibodies in ELISA, flow cytometry, and immunofluorescence applications.
• Polymer and Material Science: Functionalization of surfaces and nanomaterials with bio-recognition elements for biosensors and drug delivery systems.
• Chemical Biology Tool: For studying protein function, localization, and interactions in live cells through bioorthogonal tagging strategies.

Basic Information

Product Name	Bcn-Succinimidyl Ester
CAS No.	1516551-46-4
Molecular Formula	C₁₈H₂₄N₂O₄
Molecular Weight	332.40 g/mol
Synonyms	Bicyclo[6.1.0]nonyne NHS Ester; BCN-NHS Ester; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl N-succinimidyl carbonate; BCN-O-CO2-NHS; BCN-Carbonate-NHS; BCN active ester; BCN crosslinker; SPAAC reagent BCN-NHS
EINECS	Contact for details

Quality Control

Our Bcn-Succinimidyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the stringent requirements of pharmaceutical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.