Description

(Sp)-Hydroxymethylphenylphosphinic Acid [(-)-(1R,2S,2R)-2-I-Propyl-5-Methylcyclohexanol]Ester is a high-purity, chiral organophosphorus compound of significant interest in advanced synthetic chemistry. Its value lies in its role as a sophisticated ligand or chiral auxiliary, enabling precise stereocontrol in asymmetric catalytic reactions and the synthesis of enantiomerically pure intermediates. This product is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-fidelity chiral building blocks for developing novel active ingredients and functional materials.

Application

• Asymmetric Catalysis: Serving as a chiral ligand or catalyst precursor in transition metal-catalyzed reactions such as hydrogenation, hydroformylation, and cross-coupling.
• Pharmaceutical Intermediate Synthesis: A key chiral building block for the research and development of enantiomerically pure active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of chiral pesticides, herbicides, and plant growth regulators where specific stereochemistry is critical for activity.
• Material Science: Potential application in the development of chiral polymers, liquid crystals, or advanced functional materials with specific optical properties.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	(Sp)-Hydroxymethylphenylphosphinic Acid [(-)-(1R,2S,2R)-2-I-Propyl-5-Methylcyclohexanol]Ester
CAS No.	1508260-88-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(-)-(1R,2S,2R)-2-I-Propyl-5-Methylcyclohexanol (Sp)-Hydroxymethylphenylphosphinate; Chiral Hydroxymethylphenylphosphinic Acid Menthol Ester; (Sp)-HMPPA-Menthol Ester; Organophosphorus Chiral Ester; Asymmetric Phosphinate Ester; Ligand Precursor CAS 1508260-88-5
EINECS	Contact for details

Quality Control

Our production of this advanced chiral chemical adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment, supporting cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation. Handle and store in accordance with all applicable regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.