Description

Nemorexant is a potent and selective dual orexin receptor antagonist (DORA) with the CAS registry number 1505484-82-1. This compound is of significant interest in pharmaceutical research for its potential to modulate sleep-wake cycles by targeting the orexin neuropeptide system. It is primarily utilized by research institutions and pharmaceutical development companies engaged in neuroscience, sleep disorder research, and the development of novel central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified standard for analytical method development, validation, and quality control in drug manufacturing.
• Neuroscience Research: Used as a critical pharmacological tool to study the role of orexin receptors in sleep regulation, arousal, and related neurological pathways.
• Preclinical Drug Development: Employed in in vitro and in vivo studies to investigate the efficacy and pharmacokinetics of orexin receptor antagonists for treating insomnia and other sleep disorders.
• Biochemical Assays: Acts as a key ligand in receptor binding studies and functional assays to screen for new therapeutic candidates targeting the orexin system.
• Metabolite Identification: Used in metabolism and pharmacokinetics (DMPK) studies to identify and characterize potential metabolites.

Basic Information

Product Name	Nemorexant
CAS No.	1505484-82-1
Molecular Formula	C23H21FN4O3
Molecular Weight	420.44 g/mol
Synonyms	MK-6096; Filorexant; (2R,4R)-N-[(1S)-6-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-2,4-dimethyl-2,4,5,6,7,8-hexahydro-1H-cyclohepta[b]pyridine-1-carboxamide; (1S,2R,4R)-N-[5-(4-Fluorophenyl)-1,2,4-oxadiazol-3-yl]-2,4-dimethyl-2,4,5,6,7,8-hexahydro-1H-cyclohepta[b]pyridine-1-carboxamide; ACT-462206; Dual Orexin Receptor Antagonist (DORA)
EINECS	Contact for details

Quality Control

Our Nemorexant is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure compliance with high-grade research standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and all relevant specifications is provided with every shipment to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.