Description

5-Azaspiro[2.4]Heptane-5,6-Dicarboxylic Acid, 6-[2-(7-Bromo-9,9-Difluoro-9H-Fluoren-2-Yl)-2-Oxoethyl] 5-(1,1-Dimethylethyl) Ester, (6S)- is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fluorenyl-based structure. This compound is specifically engineered for use in the synthesis of novel active pharmaceutical ingredients (APIs), where its unique stereochemistry and functional groups are critical for biological activity. It is an essential building block for research and development teams in the pharmaceutical and biotechnology sectors, particularly those focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in medicinal chemistry programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing E3 ligase ligands or linkers due to its spirocyclic scaffold and functional handles.
• Small Molecule Drug Discovery: Used in the research and development of new chemical entities (NCEs) targeting various disease pathways.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of target APIs.
• Chemical Biology Research: Utilized as a tool compound or a precursor for labeled probes in studying protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Item	Details
Product Name	5-Azaspiro[2.4]Heptane-5,6-Dicarboxylic Acid, 6-[2-(7-Bromo-9,9-Difluoro-9H-Fluoren-2-Yl)-2-Oxoethyl] 5-(1,1-Dimethylethyl) Ester, (6S)-
CAS No.	1499193-61-1
Molecular Formula	C30H30BrF2NO5
Molecular Weight	602.47 g/mol
Synonyms	(6S)-6-[2-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl] 5-(tert-butyl) 5,6-diazaspiro[2.4]heptane-5,6-dicarboxylate; tert-Butyl (6S)-6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl] 5,6-diazaspiro[2.4]heptane-5-carboxylate; 5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl] 5-(1,1-dimethylethyl) ester, (6S)-; (6S)-5-(tert-Butoxycarbonyl)-6-[2-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-2-oxoethyl]-5,6-diazaspiro[2.4]heptane-6-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems to ensure consistency and reliability for critical R&D and scale-up processes. Our rigorous analytical protocols include HPLC, NMR, and MS to confirm identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.