Description

Methyl (2S,3S)-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-Hydroxybutanoate is a high-purity, stereochemically defined Fmoc-protected amino acid derivative, essential for the controlled synthesis of complex peptides and peptidomimetics. Its precise chiral configuration ensures the structural integrity and biological activity of the final synthesized compounds, making it a critical building block in advanced research and development. This compound is primarily utilized by pharmaceutical researchers, process chemists, and CROs/CMOs engaged in solid-phase peptide synthesis (SPPS) for the development of therapeutic peptides, diagnostic agents, and novel bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key chiral building block for the iterative assembly of peptides using Fmoc-chemistry protocols.
• Pharmaceutical Intermediate: Used in the research and development of therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Design: Incorporation into non-natural peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and targeted therapy applications.
• Chemical Biology Probes: Synthesis of tool compounds and probes for studying enzyme mechanisms, protein-protein interactions, and cellular pathways.
• Process Development: Scaling up synthesis for the production of Active Pharmaceutical Ingredients (APIs) in cGMP environments.

Basic Information

Product Name	Methyl (2S,3S)-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-Hydroxybutanoate
CAS No.	1496506-80-9
Molecular Formula	C20H21NO5
Molecular Weight	355.39 g/mol
Synonyms	Fmoc-Thr(Me)-OH; Fmoc-O-methyl-L-threonine; (2S,3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxybutanoic acid methyl ester; Methyl (2S,3S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxybutanoate; Fmoc-L-threonine methyl ester; Fmoc-Thr-OMe; Fmoc-O-Me-threonine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-threonine methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl (2S,3S)-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-Hydroxybutanoate is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and stereochemical integrity. Our products are suitable for demanding research and development applications, with specifications aligned with industry standards for advanced pharmaceutical intermediates. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, NMR, and MS data is provided with each shipment to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.