Description

1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One is a high-value pharmaceutical intermediate and advanced building block featuring a protected boronic ester functional group. This compound matters for its critical role in modern Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex, biologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly in oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for constructing biaryl and heterobiaryl structures central to medicinal chemistry.
• Chemical Synthesis Research: Used in academic and industrial R&D for exploring new synthetic pathways and creating compound libraries.
• Agrochemical Development: Potential intermediate in the synthesis of novel crop protection agents and herbicides.
• Material Science: Exploration of organic electronic materials and ligands for catalytic systems.

Basic Information

Product Name	1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One
CAS No.	1487357-03-8
Molecular Formula	C15H21BN2O3
Molecular Weight	288.15 g/mol
Synonyms	1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 1-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-one; 2-Oxo-1-methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-5-boronic acid pinacol ester; 1-Methyl-5-(pinacolatoboryl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient moisture. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.