Description

5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-isopropyl-1H-pyrazole is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, process development, and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyrazole and biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tool compounds for biological target identification and validation.
• Catalyst Ligand Synthesis: Acts as a building block for constructing sophisticated ligand systems used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical and CDMO companies offering bespoke synthesis services.

Basic Information

Product Name	5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-isopropyl-1H-pyrazole
CAS No.	1487356-83-1
Molecular Formula	C11H19BN2O2
Molecular Weight	222.10 g/mol
Synonyms	1-Isopropyl-5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrazole; 1-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (common pinacol ester analog); 5-(Dimethylglycolboron)-1-isopropylpyrazole; 1H-Pyrazole, 5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1-(1-methylethyl)-; Isopropylpyrazole boronic ester, MIDA boronate alternative; B-1H-Pyrazol-5-yl-5,5-dimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Every batch of 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-1-isopropyl-1H-pyrazole is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with each shipment, supporting compliance in GMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.