Description

1-(2-Azidoethyl)-2-Ethoxymethyl-1H-Imidazo[4,5-C]Quinolin-4-Amine is a specialized heterocyclic organic compound featuring an imidazoquinoline core functionalized with an azidoethyl group. This compound matters as a high-value synthetic intermediate, offering a unique reactive azide handle for click chemistry and bioconjugation applications. It is primarily needed by pharmaceutical and biotechnology research organizations for the development of novel immunomodulatory agents, targeted drug delivery systems, and advanced diagnostic probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of Toll-like receptor (TLR) agonists and other immunostimulatory compounds.
• Bioconjugation & Click Chemistry: The reactive azide group enables efficient, site-specific conjugation to alkyne-modified biomolecules (proteins, antibodies, oligonucleotides) for creating targeted therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new small molecule drugs targeting immune pathways.
• Diagnostic Probe Development: Serves as a precursor for fluorescent or radiolabeled probes used in cellular imaging and biomarker detection.
• Chemical Biology Tool: Employed in the study of innate immune signaling and for probing biological mechanisms involving the TLR7/8 pathway.
• Advanced Material Synthesis: Potential use in creating functionalized polymers or surfaces with bioactive properties.

Basic Information

Product Name	1-(2-Azidoethyl)-2-Ethoxymethyl-1H-Imidazo[4,5-C]Quinolin-4-Amine
CAS No.	1480600-66-5
Molecular Formula	C₁₅H₁₇N₇O
Molecular Weight	311.35 g/mol
Synonyms	1-(2-Azidoethyl)-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine; 2-(Ethoxymethyl)-1-(2-azidoethyl)-1H-imidazo[4,5-c]quinolin-4-amine; 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-azidoethyl)-2-(ethoxymethyl)-; TLR7/8 Agonist Intermediate; Azidoethyl Imidazoquinoline Amine; 1480600-66-5
EINECS	Contact for details

Quality Control

Our 1-(2-Azidoethyl)-2-Ethoxymethyl-1H-Imidazo[4,5-C]Quinolin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its light-sensitive and easily oxidized nature, prolonged exposure to light, air, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.