Description

Ezetimibe (Rss)-Isomer is a specific stereoisomer of the cholesterol absorption inhibitor, Ezetimibe. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis and study of novel therapeutic agents targeting lipid metabolism. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the development of cardiovascular drugs and metabolic disorder treatments.

Application

• Pharmaceutical Intermediate: Key chiral building block in the research and synthesis of Ezetimibe and its structural analogs.
• Active Pharmaceutical Ingredient (API) Development: Used in the development and scale-up processes for new cholesterol-lowering medications.
• Metabolic Disorder Research: A crucial reference standard and reagent in biochemical studies focused on cholesterol absorption pathways.
• Process Chemistry & Optimization: Employed in route scouting and process development for the efficient manufacturing of complex pharmaceutical molecules.
• Analytical Reference Standard: Serves as a high-purity standard for method development and quality control (HPLC, LC-MS) in analytical laboratories.

Basic Information

Product Name	Ezetimibe (Rss)-Isomer
CAS No.	1478664-18-4
Molecular Formula	C24H21F2NO3
Molecular Weight	409.43 g/mol
Synonyms	(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (Rss)-Ezetimibe; Ezetimibe Impurity; Ezetimibe Related Compound; Ezetimibe Stereoisomer; SCH 58235 Isomer; Zetia Impurity
EINECS	Contact for details

Quality Control

Our Ezetimibe (Rss)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.