Description

(S)-Benzyl 2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Cyanopropanoate CAS NO 1464137-23-2 is a high-purity, non-natural amino acid derivative protected with Fmoc and benzyl ester groups. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the introduction of a cyano functional group for further chemical elaboration. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research laboratories engaged in advanced peptide chemistry and drug discovery programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a specialized Fmoc-protected amino acid for the controlled assembly of custom peptide sequences.
• Peptidomimetic Drug Discovery: Serves as a key intermediate for creating modified peptide backbones with enhanced metabolic stability and binding affinity.
• Chemical Biology Probes: Used in the synthesis of labeled or tagged peptides for studying protein-protein interactions and enzyme activity.
• API Intermediate Development: A building block in the research-scale synthesis of potential Active Pharmaceutical Ingredients (APIs) containing non-standard amino acids.
• Academic & Contract Research: Enables synthetic chemistry research focused on novel peptide architectures and methodology development.

Basic Information

Product Name	(S)-Benzyl 2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Cyanopropanoate
CAS No.	1464137-23-2
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-Asp(CN)-OBzl; Fmoc-Aspartic acid β-cyanobenzyl ester; (S)-Benzyl 2-(((9H-fluoren-9-ylmethoxy)carbonyl)amino)-3-cyanopropanoate; Fmoc-Asp(CN)-O-Benzyl; Fmoc-L-Aspartic acid 4-cyano-benzyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-cyano-L-alanine benzyl ester; Benzyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-cyano-L-alaninate
EINECS	Contact for details

Quality Control

Our (S)-Benzyl 2-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)-3-Cyanopropanoate is manufactured under strict quality systems to ensure batch-to-batch consistency for research and development. All products undergo rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.