Description

1,2-Piperidinedicarboxylic Acid, 5-Hydroxy-, 1-(1,1-Dimethylethyl) 2-Ethyl Ester, (2S,5S)- is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules with precise three-dimensional architecture, which is critical for developing pharmaceuticals and agrochemicals with targeted biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective drug candidates.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex, enantiomerically pure molecules via reactions that exploit its stereogenic centers.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Synthesis: Potential intermediate in the development of chiral pesticides and herbicides where specific stereochemistry enhances efficacy and reduces environmental impact.
• Catalyst and Ligand Development: Can be utilized as a precursor for novel chiral catalysts or ligands used in enantioselective transformations.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity chiral intermediates.

Basic Information

Item	Details
Product Name	1,2-Piperidinedicarboxylic Acid, 5-Hydroxy-, 1-(1,1-Dimethylethyl) 2-Ethyl Ester, (2S,5S)-
CAS No.	1463501-44-1
Molecular Formula	C14H25NO5
Molecular Weight	287.35 g/mol
Synonyms	(2S,5S)-5-Hydroxypiperidine-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester; tert-Butyl (2S,5S)-5-hydroxy-2-(ethoxycarbonyl)piperidine-1-carboxylate; (2S,5S)-1-Boc-5-hydroxy-2-piperidinecarboxylic acid ethyl ester; (2S,5S)-1-(tert-Butoxycarbonyl)-5-hydroxy-2-piperidinecarboxylic acid ethyl ester; (2S,5S)-Ethyl 1-Boc-5-hydroxypiperidine-2-carboxylate; (2S,5S)-Ethyl 5-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-2-carboxylate; (2S,5S)-1-N-Boc-5-hydroxypipecolic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 1,2-Piperidinedicarboxylic Acid, 5-Hydroxy-, 1-(1,1-Dimethylethyl) 2-Ethyl Ester, (2S,5S)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.