Description

tert-Butyl 4,7-Diazaspiro[2.5]Octane-7-Carboxylate Hydrochloride is a high-purity, protected diazaspiro building block essential for advanced pharmaceutical research and development. This compound is a critical intermediate in the synthesis of complex molecules, particularly for drug discovery programs targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeted drugs.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to introduce the constrained diazaspiro scaffold.
• Process Chemistry: Serves as a versatile intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: Utilized in the construction of linkers and warhead components for targeted protein degradation platforms.
• Chemical Biology Probes: Incorporated into tool compounds for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Item	Details
Product Name	tert-Butyl 4,7-Diazaspiro[2.5]Octane-7-Carboxylate Hydrochloride
CAS No.	1462383-16-9
Molecular Formula	C11H21ClN2O2
Molecular Weight	248.75 g/mol
Synonyms	7-Boc-4,7-diazaspiro[2.5]octane hydrochloride; tert-Butyl 4,7-diazaspiro[2.5]octane-7-carboxylate HCl; 4,7-Diazaspiro[2.5]octane-7-carboxylic acid, 1,1-dimethylethyl ester, hydrochloride; 7-(tert-Butoxycarbonyl)-4,7-diazaspiro[2.5]octane hydrochloride; Boc-4,7-diazaspiro[2.5]octane hydrochloride; 1-Boc-4,7-diazaspiro[2.5]octane hydrochloride; 1462383-16-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 4,7-Diazaspiro[2.5]Octane-7-Carboxylate Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.