Description

(S)-1'-(tert-Butyl)-2'-Oxo-1',2',5,7-Tetrahydrospiro[Cyclopenta[B]Pyridine-6,3'-Pyrrolo[2,3-B]Pyridine]-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and fused heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, particularly in the synthesis of novel, targeted therapeutic agents. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs) for challenging disease targets.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique spirocyclic scaffold.
• API Development: Serves as a critical precursor in the multi-step synthesis of complex, high-value active pharmaceutical ingredients.
• Biochemical Tool Compound: Potential use in developing probes for studying biological pathways and enzyme inhibition.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	(S)-1'-(tert-Butyl)-2'-Oxo-1',2',5,7-Tetrahydrospiro[Cyclopenta[B]Pyridine-6,3'-Pyrrolo[2,3-B]Pyridine]-3-Carboxylic Acid
CAS No.	1455358-16-3
Molecular Formula	C22H23N3O3
Molecular Weight	377.44 g/mol
Synonyms	(S)-1'-(tert-Butyl)-2'-oxo-1',2',5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid; 1455358-16-3; Spiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridine]-3-carboxylic acid derivative; tert-Butyl spirocyclic pyridine-pyrrolopyridine carboxylic acid; (S)-enantiomer of CAS 1455358-16-3
EINECS	Contact for details

Quality Control

Our production of (S)-1'-(tert-Butyl)-2'-Oxo-1',2',5,7-Tetrahydrospiro[Cyclopenta[B]Pyridine-6,3'-Pyrrolo[2,3-B]Pyridine]-3-Carboxylic Acid adheres to stringent quality management protocols. Every batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.