Description

(S)-1'-(tert-Butyl)-3-Chloro-5,7-Dihydrospiro[Cyclopenta[B]Pyridine-6,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic structure. This compound is of significant value for its role as a critical building block in the research and development of novel therapeutic agents, particularly in kinase inhibitor programs. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of investigational kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its privileged scaffold.
• Process Chemistry Development: Serves as a benchmark compound for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) guidelines.
• Biochemical Assay Development: Employed as a reference standard or ligand in high-throughput screening and binding assays.
• Academic Research: Utilized in universities and research institutes for studying heterocyclic chemistry and asymmetric synthesis methodologies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines for global clients.

Basic Information

Product Name	(S)-1'-(tert-Butyl)-3-Chloro-5,7-Dihydrospiro[Cyclopenta[B]Pyridine-6,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One
CAS No.	1455358-14-1
Molecular Formula	C19H20ClN3O
Molecular Weight	341.84 g/mol
Synonyms	(S)-1'-(tert-Butyl)-3-chloro-1'H,5H-spiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'-one; (S)-3-Chloro-1'-(tert-butyl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; 1455358-14-1; UNII-8I3K4F8K7G; 8I3K4F8K7G; Spiro[cyclopenta[b]pyridine-6,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one, (S)-1'-(1,1-dimethylethyl)-3-chloro-5,7-dihydro-; AOB 67707; BCP33222; ZINC000253864991.
EINECS	Contact for details

Quality Control

Our (S)-1'-(tert-Butyl)-3-Chloro-5,7-Dihydrospiro[Cyclopenta[B]Pyridine-6,3'-Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting research-grade and cGMP standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency for your critical R&D and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.