Description

1-(tert-Butyl)-3-((5-Chloro-3-(Hydroxymethyl)Pyridin-2-Yl)Methyl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in oncology and other disease areas. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring precise molecular building blocks for complex synthesis pathways.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of active pharmaceutical ingredients (APIs) for targeted therapies.
• Oncology Research: Used in the synthesis of investigational new drugs (INDs) targeting specific cancer pathways.
• Kinase Inhibitor Development: A crucial scaffold for creating potent and selective kinase inhibitors due to its fused pyrrolopyridine core.
• Biochemical Research: Employed in academic and industrial research to study protein-ligand interactions and structure-activity relationships (SAR).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke organic synthesis for clients.
• Process Chemistry: Used in route scouting and scale-up optimization for the commercial manufacturing of complex drug molecules.

Basic Information

Item	Detail
Product Name	1-(tert-Butyl)-3-((5-Chloro-3-(Hydroxymethyl)Pyridin-2-Yl)Methyl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One
CAS No.	1455358-11-8
Molecular Formula	C18H20ClN3O2
Molecular Weight	345.82 g/mol
Synonyms	1-(tert-Butyl)-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 1-(tert-Butyl)-3-[(5-chloro-3-hydroxymethyl-2-pyridyl)methyl]pyrrolo[2,3-b]pyridin-2(1H)-one; 2H-Pyrrolo[2,3-b]pyridin-2-one, 1-(1,1-dimethylethyl)-3-[[5-chloro-3-(hydroxymethyl)-2-pyridinyl]methyl]-1,3-dihydro-; CAS 1455358-11-8; 1-tert-Butyl-3-((5-chloro-3-(hydroxymethyl)pyridin-2-yl)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.