Description

2H-Pyrrolo[2,3-B]Pyridin-2-One, 3-[[5-Chloro-3-[[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Methyl]-2-Pyridinyl]Methylene]-1-(1,1-Dimethylethyl)-1,3-Dihydro-, (3E)- is a sophisticated heterocyclic organic compound designed as a key pharmaceutical intermediate or research chemical. Its complex molecular architecture, featuring a pyrrolopyridinone core with a protected hydroxymethyl pyridine moiety, makes it a critical building block in modern drug discovery. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for investigational drugs.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Development: The pyrrolopyridinone structure is common in kinase inhibitors, making this compound valuable for oncology and anti-inflammatory drug research.
• Chemical Biology Probes: Utilized in the development of molecular probes to study specific biological pathways and target validation.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of candidate drugs.
• Contract Research & Manufacturing (CRO/CMO): A key material for organizations providing custom synthesis and development services.

Basic Information

Product Name	2H-Pyrrolo[2,3-B]Pyridin-2-One, 3-[[5-Chloro-3-[[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Methyl]-2-Pyridinyl]Methylene]-1-(1,1-Dimethylethyl)-1,3-Dihydro-, (3E)-
CAS No.	1455358-09-4
Molecular Formula	C23H26ClN3O3
Molecular Weight	427.92 g/mol
Synonyms	(3E)-3-[[5-Chloro-3-[[(Tetrahydro-2H-pyran-2-yl)oxy]methyl]-2-pyridinyl]methylene]-1-(1,1-dimethylethyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 1-tert-Butyl-3-[(5-chloro-3-[(tetrahydro-2H-pyran-2-yloxy)methyl]pyridin-2-yl)methylene]-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one (E)-isomer; 1455358-09-4; THP-protected pyrrolopyridinone derivative; tert-Butyl pyrrolopyridinone intermediate
EINECS	Contact for details

Quality Control

Our 2H-Pyrrolo[2,3-B]Pyridin-2-One intermediate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided, and we support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive and/or hygroscopic; handling under an inert atmosphere is recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.