Description

1-(tert-Butyl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One is a high-purity, advanced pharmaceutical intermediate with a complex fused heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapies.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new bioactive molecules.
• API Synthesis: Used in the production of active pharmaceutical ingredients that require the specific pyrrolopyridine pharmacophore.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard in analytical method development for pharmacokinetic studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	1-(tert-Butyl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One
CAS No.	1455358-06-1
Molecular Formula	C11H14N2O
Molecular Weight	190.24 g/mol
Synonyms	1-(tert-Butyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 1-tert-Butyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 1-(1,1-Dimethylethyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 2H-Pyrrolo[2,3-b]pyridin-2-one, 1-(1,1-dimethylethyl)-1,3-dihydro-; 1-(tert-Butyl)-2-oxo-1,2-dihydro-3H-pyrrolo[2,3-b]pyridine; tert-Butyl pyrrolopyridinone derivative; CAS 1455358-06-1
EINECS	Contact for details

Quality Control

Our 1-(tert-Butyl)-1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material that meets stringent in-house standards and can be produced under cGMP guidelines for advanced clinical phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this moisture-sensitive compound.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.