Description

5-Chloro-3-(((Tetrahydro-2H-Pyran-2-Yl)Oxy)Methyl)Picolinaldehyde is a high-purity, advanced pharmaceutical intermediate featuring a protected aldehyde and a chlorinated pyridine core. This compound matters for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling precise molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex drug molecules, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the chloropyridine moiety is a common active component.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Organic Synthesis Building Block: The protected aldehyde group allows for selective functionalization in multi-step synthetic sequences.
• Material Science Research: Employed in the synthesis of organic electronic materials and functional polymers.

Basic Information

Item	Details
Product Name	5-Chloro-3-(((Tetrahydro-2H-Pyran-2-Yl)Oxy)Methyl)Picolinaldehyde
CAS No.	1455358-05-0
Molecular Formula	C12H14ClNO3
Molecular Weight	255.70 g/mol
Synonyms	5-Chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)picolinaldehyde; 5-Chloro-3-((tetrahydro-2H-pyran-2-yloxy)methyl)picolinaldehyde; 2-Pyridinecarboxaldehyde, 5-chloro-3-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-; 5-Chloro-3-(THP-oxymethyl)picolinaldehyde; 5-Chloro-3-((THPO)methyl)picolinaldehyde; 5-Chloro-3-(tetrahydropyran-2-yloxymethyl)pyridine-2-carbaldehyde
EINECS	Contact for details

Quality Control

Our 5-Chloro-3-(((Tetrahydro-2H-Pyran-2-Yl)Oxy)Methyl)Picolinaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.