Description

(R)-5-Boc-5-Azaspiro[2.4]Heptane-6-Carboxylic Acid is a high-purity, chiral spirocyclic building block of significant value in modern organic synthesis. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel bioactive molecules, leveraging its constrained spirocyclic scaffold.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and route development for new chemical entities (NCEs).
• Agrochemical Synthesis: Employed in the research and development of novel pesticides and herbicides, where its unique structure can impart specific biological activity.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective reactions to introduce complexity and defined stereochemistry into target molecules.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying enzyme function or protein-protein interactions due to its three-dimensional structure.

Basic Information

Product Name	(R)-5-Boc-5-Azaspiro[2.4]Heptane-6-Carboxylic Acid
CAS No.	1454843-78-7
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	(R)-6-(tert-Butoxycarbonyl)-6-azaspiro[2.4]heptane-5-carboxylic acid; (5R)-5-[(1,1-Dimethylethoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid; (R)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid; (R)-N-Boc-5-azaspiro[2.4]heptane-6-carboxylic acid; (R)-5-Azaspiro[2.4]heptane-6-carboxylic acid, 5-(1,1-dimethylethyl) ester; (R)-5-Boc-5-azaspiro[2.4]heptane-6-carboxylic acid; tert-Butyl (6R)-6-carboxy-5-azaspiro[2.4]heptane-5-carboxylate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. We employ validated analytical methods, including HPLC, GC, and NMR, to guarantee identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, providing batch-specific data for critical parameters such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.