Description

5-Azaspiro[2.4]Heptane-5,6-Dicarboxylic Acid, 5-(1,1-Dimethylethyl) Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates targeting neurological disorders.
• Protease Inhibitor Development: Used in research and development of protease inhibitors for antiviral and anticancer therapies.
• Ligand Synthesis: Serves as a precursor for complex ligands in asymmetric catalysis and medicinal chemistry.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Academic & Institutional Research: Employed in university and research institute laboratories for exploratory synthetic chemistry and drug discovery projects.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and scale-up services for the pharmaceutical industry.

Basic Information

Item	Detail
Product Name	5-Azaspiro[2.4]Heptane-5,6-Dicarboxylic Acid, 5-(1,1-Dimethylethyl) Ester
CAS No.	1454843-77-6
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	5-tert-Butyl 6-methyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate; 5-(tert-Butoxycarbonyl)-6-(methoxycarbonyl)-5-azaspiro[2.4]heptane; 5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-tert-butyl ester; tert-Butyl 6-(methoxycarbonyl)-5-azaspiro[2.4]heptane-5-carboxylate; 5-Boc-6-(COOMe)-5-azaspiro[2.4]heptane; Spirocyclic proline derivative ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 5-Azaspiro[2.4]Heptane-5,6-Dicarboxylic Acid, 5-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) confirming identity, purity (typically >97% by HPLC), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.