Description

(1R,3R,5S)-6'-Bromo-3,5-Dimethylspiro[Cyclohexane-1,2'-Indene]-1',4(3'H)-Dione is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and brominated indandione structure. This compound is of significant value for its role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the discovery of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and development of new drug candidates, particularly in therapeutic areas requiring complex molecular architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its unique spirocyclic and bromine functional group.
• Organic Synthesis: Serves as a versatile precursor for synthesizing more complex heterocyclic compounds and fine chemicals through various coupling and functionalization reactions.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential commercial drug manufacturing.
• Academic Research: Utilized in universities and research institutes for studying novel synthetic methodologies and reaction mechanisms involving brominated spiro compounds.

Basic Information

Product Name	(1R,3R,5S)-6'-Bromo-3,5-Dimethylspiro[Cyclohexane-1,2'-Indene]-1',4(3'H)-Dione
CAS No.	1454700-85-6
Molecular Formula	C₁₇H₁₉BrO₂
Molecular Weight	335.24 g/mol
Synonyms	6'-Bromo-3,5-dimethylspiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione; (1R,3R,5S)-6'-Bromo-3,5-dimethylspiro[cyclohexane-1,2'-indene]-1',4-dione; 6'-Bromo-3,5-dimethylspiro[cyclohexane-1,2'-indene]-1',4-dione; (1R,3R,5S)-6'-Bromo-3,5-dimethyl-1',4-dioxospiro[cyclohexane-1,2'-indane]; Spiro[cyclohexane-1,2'-indene]-1',4(3'H)-dione, 6'-bromo-3,5-dimethyl-, (1R,3R,5S)-; 1454700-85-6
EINECS	Contact for details

Quality Control

Our (1R,3R,5S)-6'-Bromo-3,5-Dimethylspiro[Cyclohexane-1,2'-Indene]-1',4(3'H)-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be handled and stored under an inert atmosphere to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.