Description

3-Carboxy-2-Chloropyridine-5-Boronic Acid is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its unique structure, combining a carboxylic acid, a boronic acid pinacol ester precursor, and a halogenated pyridine core, makes it a critical intermediate for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its halogen and boronic acid functionalities for structural diversification.
• Material Science Research: Serves as a precursor for creating functionalized polymers, ligands for catalysts, and organic electronic materials.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3-Carboxy-2-Chloropyridine-5-Boronic Acid
CAS No.	1451393-50-2
Molecular Formula	C6H5BClNO4
Molecular Weight	201.37 g/mol
Synonyms	2-Chloro-5-borono-3-pyridinecarboxylic acid; (2-Chloro-5-carboxypyridin-3-yl)boronic acid; 5-Borono-2-chloronicotinic acid; 3-Pyridinecarboxylic acid, 2-chloro-5-borono-; 2-Chloro-5-(dihydroxyboryl)nicotinic acid; 1451393-50-2
EINECS	Contact for details

Quality Control

Every batch of 3-Carboxy-2-Chloropyridine-5-Boronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and LC-MS are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.