Description

2-Bromo-3-Carboxypyridine-5-Boronic Acid is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. Its unique structure, incorporating both a bromo substituent and a boronic acid group on a pyridine carboxylic acid scaffold, makes it a versatile precursor for cross-coupling reactions and further derivatization. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for constructing biaryl and heterobiaryl systems found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyridine-based architectures.
• Material Science Research: Serves as a precursor for creating functionalized organic ligands, metal-organic frameworks (MOFs), and organic electronic materials.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological systems and enzyme activity.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Product Name	2-Bromo-3-Carboxypyridine-5-Boronic Acid
CAS No.	1451393-49-9
Molecular Formula	C7H5BBrNO4
Molecular Weight	245.84 g/mol
Synonyms	5-Borono-2-bromonicotinic Acid; (5-Bromo-6-carboxypyridin-3-yl)boronic Acid; 2-Bromo-5-borono-nicotinic Acid; 3-Bromo-5-carboxypyridine-2-boronic Acid; 2-Bromo-3-pyridinecarboxylic-5-boronic Acid; 2-Bromo-5-(dihydroxyboranyl)pyridine-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Carboxypyridine-5-Boronic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and regulatory submissions. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity confirmation (by 1H NMR and IR), and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.