Description

Cy5.5 Carboxylic Acids CAS NO 1449661-34-0 are a class of functionalized cyanine dyes featuring a reactive carboxylic acid group, enabling covalent conjugation to biomolecules like proteins, peptides, and antibodies. This compound is essential for creating highly sensitive and stable near-infrared (NIR) fluorescent probes for advanced diagnostic and research applications. It is primarily needed by biotechnology, pharmaceutical, and diagnostic kit manufacturers engaged in molecular imaging, flow cytometry, and in vivo tracking.

Application

• Bioconjugation for NIR Fluorescent Probes: Covalent labeling of antibodies, proteins, and peptides for sensitive detection in assays.
• In Vivo Imaging Agent Synthesis: Development of targeted contrast agents for non-invasive optical imaging in preclinical research.
• Flow Cytometry & Microscopy: Creation of bright, photostable fluorescent tags for cell sorting and high-resolution cellular imaging.
• Diagnostic Assay Development: Key component in lateral flow assays (LFAs) and ELISA kits requiring NIR fluorescence detection.
• Polymer & Nanoparticle Functionalization: Modification of drug delivery carriers and polymeric materials with targeting or imaging moieties.
• DNA/RNA Labeling: Synthesis of labeled nucleotides or oligonucleotides for genomic and transcriptomic analysis.

Basic Information

Product Name	Cy5.5 Carboxylic Acids
CAS No.	1449661-34-0
Molecular Formula	C44H47ClN2O4+ (as a common salt form)
Molecular Weight	~703.32 g/mol (for chloride salt)
Synonyms	Sulfo-Cyanine5.5 carboxylic acid; Cy5.5 NHS ester precursor; 1H-Benz[e]indolium, 2-[5-(1-carboxypentyl)-9-chloro-7-(2-sulfoethyl)-3H-benz[e]indol-3-ylidene]-1-ethyl-7-(2-sulfoethyl)-, inner salt; NIR dye carboxylic acid; Cyanine5.5 COOH; CAS 1449661-34-0; Near-infrared fluorescent dye acid
EINECS	Contact for details

Quality Control

Our Cy5.5 Carboxylic Acids are produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and spectrophotometry to validate optical properties. Certificates of Analysis (COA) detailing purity, identity, and performance specifications are available upon request to ensure compliance with your research and manufacturing standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	Dark green to blue solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95% (Area % at λ max)
Absorption (λ max)	683 ± 5 nm
Emission (λ max)	703 ± 5 nm
Extinction Coefficient (ε)	≥ 190,000 cm-1M-1
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.