Description

Azido-PEG5-CH2CO2T-butyl ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a protected carboxylic acid. This compound is essential for creating stable, biocompatible conjugates in advanced bioconjugation and materials science applications. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and the synthesis of functionalized biomaterials and drug delivery systems.

Application

• Bioconjugation and Click Chemistry: The azide terminus enables efficient copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) with alkynes for labeling proteins, antibodies, and oligonucleotides.
• PEGylation Reagent: Used to introduce PEG chains onto drug molecules, peptides, or surfaces to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Crosslinking Agent: Serves as a spacer in the synthesis of hydrogels, polymer networks, and surface coatings where controlled linkage is required.
• Proteomics Research: Facilitates the study of protein-protein interactions and cellular processes through site-specific modification.
• ADC (Antibody-Drug Conjugate) Development: Acts as a key component in constructing linkers for attaching cytotoxic payloads to targeting antibodies.
• Materials Science: Employed to functionalize nanoparticles, quantum dots, and other nanomaterials for diagnostic and therapeutic applications.
• Diagnostic Reagent Synthesis: Used in creating reagents for assays, imaging probes, and biosensors.

Basic Information

Product Name	Azido-PEG5-CH2CO2T-butyl ester
CAS No.	1448451-72-6
Molecular Formula	C22H43N3O8
Molecular Weight	477.60 g/mol
Synonyms	Azido-PEG5-acid T-butyl ester; 2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid 1,1-dimethylethyl ester; 1-tert-Butyl 2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetate; Azido-Pentaethylene glycol-CH2COOtBu; N3-PEG5-t-butyl ester; Azido-OEG5-acid t-butyl ester; 3-Azidopropyl-PEG5-t-butyl ester (related structure); tert-Butyl 2,5,8,11,14-pentaoxa-17-azaheptadecan-17-oate-1-azide
EINECS	Contact for details

Quality Control

Our Azido-PEG5-CH2CO2T-butyl ester is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research and cGMP-grade material standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. The product is moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.