Description

Methyl 7-Chloro-5-Oxo-1-Tosyl-2,3,4,5,-Tetrahydro-1H-Benzo[B]Azepine-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. This compound serves as a critical building block for the development of novel therapeutic agents, particularly within the benzazepine class of molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex active pharmaceutical ingredients (APIs) and new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of benzazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in research and development (R&D) for the design, synthesis, and screening of new drug candidates targeting central nervous system (CNS) and other disorders.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial drug substances.
• Academic Research: Utilized in university and institutional laboratories for studies in heterocyclic chemistry and novel synthetic methodology development.

Basic Information

Product Name	Methyl 7-Chloro-5-Oxo-1-Tosyl-2,3,4,5,-Tetrahydro-1H-Benzo[B]Azepine-4-Carboxylate
CAS No.	1448365-49-8
Molecular Formula	C20H20ClNO5S
Molecular Weight	421.89 g/mol
Synonyms	Methyl 7-chloro-5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylate; 1H-Benzo[b]azepine-4-carboxylic acid, 2,3,4,5-tetrahydro-7-chloro-5-oxo-1-[(4-methylphenyl)sulfonyl]-, methyl ester; 4-Carbomethoxy-7-chloro-5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepine; Methyl 4,5-dihydro-7-chloro-5-oxo-1-tosyl-1H-benzo[b]azepine-4-carboxylate; 7-Chloro-4-(methoxycarbonyl)-5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine
EINECS	Contact for details

Quality Control

Our Methyl 7-Chloro-5-Oxo-1-Tosyl-2,3,4,5,-Tetrahydro-1H-Benzo[B]Azepine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.