Description

Ethyl 6,6-Difluorospiro[2.5]Octane-1-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated molecular architecture. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex, fluorine-containing target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce fluorinated spirocyclic motifs, which can improve drug-like properties.
• Agrochemical Synthesis: Serves as a precursor for developing new-generation herbicides and pesticides with the spirocyclic difluoro moiety contributing to biological activity.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced materials requiring specific steric and electronic properties.
• Fluorine Chemistry: A valuable substrate for further synthetic elaboration in organofluorine chemistry, exploring new C-F bond transformations.

Basic Information

Product Name	Ethyl 6,6-Difluorospiro[2.5]Octane-1-Carboxylate
CAS No.	1447942-88-2
Molecular Formula	C11H16F2O2
Molecular Weight	218.24 g/mol
Synonyms	Ethyl 6,6-Difluoro-1-oxaspiro[2.5]octane-5-carboxylate; 6,6-Difluorospiro[2.5]octane-1-carboxylic Acid Ethyl Ester; 1-Oxaspiro[2.5]octane-5-carboxylic acid, 6,6-difluoro-, ethyl ester; Ethyl 6,6-difluoro-1-oxaspiro[2.5]octane-5-carboxylate; Difluorospirooctane Carboxylate Ester
EINECS	Contact for details

Quality Control

Our Ethyl 6,6-Difluorospiro[2.5]Octane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.