Description

(R)-4-Fluoroleucine Ethyl Ester is a high-purity, non-natural amino acid derivative featuring a fluorine atom at the gamma position of the leucine side chain. This chiral building block is critical for introducing fluorine into peptides and bioactive molecules, enhancing their metabolic stability, lipophilicity, and binding affinity. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of novel therapeutics, including protease inhibitors and PET (Positron Emission Tomography) imaging agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide-based drugs and protease inhibitors.
• PET Radiopharmaceutical Precursor: Serves as a precursor for labeling with fluorine-18 (18F) to create diagnostic imaging agents.
• Medicinal Chemistry Research: Used to study structure-activity relationships (SAR) by incorporating fluorine into lead compounds to modulate bioavailability and potency.
• Bioconjugation & Peptide Engineering: Enables the site-specific introduction of fluorine tags into peptides and proteins for biochemical studies.
• Agrochemical Synthesis: Employed in the research and development of advanced, fluorinated active ingredients with improved efficacy.
• Asymmetric Synthesis: Acts as a valuable chiral auxiliary or building block in stereoselective organic synthesis.

Basic Information

Product Name	(R)-4-Fluoroleucine Ethyl Ester
CAS No.	1447694-63-4
Molecular Formula	C8H16FNO2
Molecular Weight	177.22 g/mol
Synonyms	(R)-2-Amino-4-fluoro-4-methylpentanoic acid ethyl ester; Ethyl (2R)-2-amino-4-fluoro-4-methylpentanoate; (R)-4-Fluoro-leucine ethyl ester; D-4-Fluoroleucine ethyl ester; (R)-4-Fluoro-L-leucine ethyl ester; 4-Fluoro-D-leucine ethyl ester; (R)-4-Fluoronorleucine ethyl ester
EINECS	Contact for details

Quality Control

Our (R)-4-Fluoroleucine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR, and MS for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and specific impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.