Description

Bromo-Peg2-Phosphonic Acid is a bifunctional organic compound that serves as a versatile building block in advanced chemical synthesis. Its unique structure, combining a reactive bromoalkyl terminus with a phosphonic acid group via a polyethylene glycol (PEG) spacer, enables precise conjugation and surface modification strategies. This product is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors who require high-purity linkers for developing targeted therapies, diagnostic agents, and functionalized nanomaterials.

Application

• Bioconjugation Reagent: Used to attach drugs, dyes, or other functional molecules to proteins, antibodies, or nanoparticles via the reactive bromo group, while the phosphonic acid aids in solubility or provides an anchor point.
• Pharmaceutical Intermediate: Serves as a key synthon in the development of prodrugs and targeted therapeutic agents, particularly in antibody-drug conjugates (ADCs) and small molecule inhibitors.
• Surface Functionalization: The phosphonic acid group allows for stable binding to metal oxide surfaces (e.g., titanium, iron oxide), making it valuable for creating biofunctional coatings on medical implants or diagnostic platforms.
• Polymer Modification: Acts as a chain transfer agent or functional initiator in controlled radical polymerization (e.g., ATRP) to synthesize polymers with tailored end-group functionality.
• Ligand for Catalysis: Can be utilized to create phosphonate-based ligands for metal complexes used in homogeneous catalysis.
• Crosslinking Agent: Employed in the synthesis of hydrogels or polymer networks where the bromo group participates in further chemical reactions.

Basic Information

Product Name	Bromo-Peg2-Phosphonic Acid
CAS No.	1446282-44-5
Molecular Formula	C7H16BrO6P
Molecular Weight	307.08 g/mol
Synonyms	2-[2-(2-Bromoethoxy)ethoxy]ethylphosphonic acid; (2-{2-[2-Bromoethoxy]ethoxy}ethyl)phosphonic acid; Bromo-dPEG®2-phosphonic acid; Br-PEG2-phosphonic acid; 2-(2-(2-Bromoethoxy)ethoxy)ethanephosphonic acid; Bromo(triethylene glycol) phosphonate; α-Bromo-ω-phosphonic acid-PEG2
EINECS	Contact for details

Quality Control

Our Bromo-Peg2-Phosphonic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR (¹H and ³¹P) for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.