Description

Tfp-Peg4-Tfp CAS NO 1446282-42-3 is a specialized heterobifunctional polyethylene glycol (PEG) crosslinker featuring two tetrafluorophenyl (TFP) ester reactive groups. This compound is engineered for efficient and selective conjugation chemistry, enabling the stable linkage of biomolecules under mild aqueous conditions. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, advanced drug delivery systems, and the development of diagnostic assays.

Application

• Bioconjugation reagent for linking proteins, peptides, or antibodies to surfaces, nanoparticles, or other biomolecules.
• Crosslinker in the synthesis of hydrogels and polymer networks for controlled drug release applications.
• Intermediate in the preparation of antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Surface functionalization of materials for biosensors and diagnostic platforms.
• Tool compound in proteomics research for studying protein-protein interactions.
• Modification of oligonucleotides or other nucleic acid-based therapeutics.

Basic Information

Product Name	Tfp-Peg4-Tfp
CAS No.	1446282-42-3
Molecular Formula	C26H26F4O9
Molecular Weight	558.48 g/mol
Synonyms	1,3,5-Tris(2,3,5,6-tetrafluorophenoxy)benzene-4,4',4''-triyltriacetic acid PEG4 ester; Tetrafluorophenyl-PEG4-tetrafluorophenyl ester; TFP-PEG4-TFP ester; Bis(2,3,5,6-tetrafluorophenyl) 3,6,9,12-tetraoxatetradecanedioate; Heterobifunctional PEG crosslinker, TFP terminated; 2,3,5,6-Tetrafluorophenyl 3,6,9,12-tetraoxatetradecanedioate; TFP-PEG4-acid-TFP (common descriptor)
EINECS	Contact for details

Quality Control

Our Tfp-Peg4-Tfp is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation by NMR and MS. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store the product in a freezer at -20°C to -10°C under desiccant. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.