Description

Bromo-Peg5-Phosphonic Acid Ethyl Ester is a high-purity, functionalized PEG linker featuring a terminal bromo group and a phosphonic acid ethyl ester moiety. This bifunctional compound is engineered to serve as a versatile building block for the synthesis of complex molecules, enabling precise conjugation and modification. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and materials science who require reliable, high-quality intermediates for creating targeted drug delivery systems, diagnostic probes, and advanced polymeric materials.

Application

• Pharmaceutical Linker: A key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Bioconjugation Reagent: Used to attach drugs, dyes, or other functional molecules to proteins, peptides, or nanoparticles via the reactive bromo group.
• Polymer Modification: Serves as a functional monomer or chain-transfer agent for introducing phosphonate groups into polymers for enhanced properties.
• Surface Functionalization: Employed to modify material surfaces (e.g., metals, oxides) with PEG-phosphonate layers to improve biocompatibility and reduce non-specific binding.
• Prodrug Synthesis: Utilized in creating prodrugs where the phosphonate ester acts as a cleavable linker for controlled drug release.
• Chemical Biology Probes: Facilitates the development of tools for studying biological processes through selective labeling.

Basic Information

Product Name	Bromo-Peg5-Phosphonic Acid Ethyl Ester
CAS No.	1446282-41-2
Molecular Formula	C17H36BrNO10P
Molecular Weight	516.34 g/mol
Synonyms	Bromo-PEG5-phosphonic acid ethyl ester; 2-[2-[2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethylphosphonic acid ethyl ester; 15-Bromo-4,7,10,13-tetraoxa-1-phosphapentadecan-1-one, 1-ethyl ester, 1-oxide; Bromo(tetraethylene glycol)ethyl ether phosphonic acid ethyl ester; Br-PEG5-P(O)(OEt)OH; Bromo-PEG5-phosphonate ethyl ester; Ethyl 2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethylphosphonate
EINECS	Contact for details

Quality Control

Our Bromo-Peg5-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your research and cGMP-compliant manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a desiccator to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.