Description

Diethoxy-Phosphorylethyl-Peg5-Ethylphosphonic Acid is a specialized bifunctional organophosphorus compound featuring a polyethylene glycol (PEG) spacer, designed for advanced material science and bioconjugation applications. This unique structure provides a versatile linker that combines the hydrophilic, non-immunogenic properties of PEG with the strong metal-chelating and surface-modifying capabilities of phosphonic acid groups. It is essential for researchers and manufacturers in the pharmaceutical, nanotechnology, and specialty polymer industries who require precise surface engineering, controlled drug delivery systems, or stable metal-organic frameworks.

Application

• Bioconjugation & Drug Delivery: Serves as a critical linker for attaching therapeutic agents, targeting ligands, or imaging probes to nanoparticles, proteins, or other biomolecules, enhancing solubility and circulation time.
• Surface Functionalization: Used to modify the surface of metal oxides (e.g., titanium, iron oxide) and hydroxyapatite for biomedical implants, biosensors, and diagnostic devices to improve biocompatibility and functionality.
• Nanoparticle Stabilization: Acts as a stabilizing agent for quantum dots, gold nanoparticles, and other inorganic nanocrystals, providing colloidal stability in aqueous media.
• Metal Chelation & Separation: Employed in the development of chelating resins, membranes, or solutions for selective metal ion recovery, catalysis, or wastewater treatment.
• Advanced Material Synthesis: A key monomer or cross-linker in the synthesis of functional polymers, hydrogels, and hybrid organic-inorganic materials with tailored properties.
• Dental & Bone Cement Modifiers: Incorporated into formulations to enhance the adhesion and integration of cements with tooth enamel or bone tissue.

Basic Information

Product Name	Diethoxy-Phosphorylethyl-Peg5-Ethylphosphonic Acid
CAS No.	1446282-17-2
Molecular Formula	C21H46O13P2
Molecular Weight	568.5 g/mol (approx.)
Synonyms	2-[2-[2-[2-[2-[2-(Diethoxyphosphoryl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylphosphonic acid; PEG5-bisphosphonate linker; (Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(phosphonic acid) PEG derivative; Phosphonic acid, P-[2-[2-[2-[2-[2-(2-phosphonoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]-, diethyl ester; Bisphosphonate-PEG5-acid; Heterobifunctional PEG phosphonate; Diethyl (PEG5-ethylphosphonate) phosphonate
EINECS	Contact for details

Quality Control

Our Diethoxy-Phosphorylethyl-Peg5-Ethylphosphonic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with precise specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP standards for applications requiring high levels of traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.