Description

Racemic-(2R,5R)-tert-Butyl 2-(Hydroxymethyl)-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate (Wx102240) is a sophisticated chiral spirocyclic building block of significant interest in advanced organic synthesis. This compound is valued for its rigid, three-dimensional scaffold and the presence of orthogonal protecting groups, which enable precise and complex molecular construction. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of protease inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for targeting infectious diseases and central nervous system disorders.
• Protease Inhibitor Scaffold: Serves as a core structural element for designing potent inhibitors of enzymes like HCV NS3/4A protease, HIV protease, and others.
• Agrochemical Synthesis: Used in the creation of novel, high-performance pesticides and herbicides that require specific stereochemistry for optimal activity.
• Asymmetric Catalysis Ligand Precursor: The spirocyclic structure can be modified to create novel chiral ligands for asymmetric hydrogenation and other catalytic transformations.
• Chemical Biology Probe Development: Employed in the synthesis of molecular tools for studying enzyme function and protein-protein interactions within biological systems.
• Peptidomimetic Research: Its constrained, non-peptide backbone makes it an ideal building block for creating stable peptidomimetics with enhanced metabolic stability.

Basic Information

Product Name	Racemic-(2R,5R)-tert-Butyl 2-(Hydroxymethyl)-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate (Wx102240)
CAS No.	1446012-37-8
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	tert-Butyl (2R,5R)-2-(hydroxymethyl)-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate; (±)-(2R,5R)-7-Boc-2-(hydroxymethyl)-1-oxa-7-azaspiro[4.4]nonane; 1-Oxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R,5R)-; WX-102240; Wx102240; Spirocyclic oxazolidine Boc-protected amine; Boc-protected spirocyclic amino alcohol.
EINECS	Contact for details

Quality Control

Our production of Racemic-(2R,5R)-tert-Butyl 2-(Hydroxymethyl)-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive pharmaceutical R&D. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	Racemic mixture (1:1 ratio)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.