Description

5-Bromo-3-Fluoro-2-(Methylsulfonyl)Pyridine is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a methylsulfonyl group on a pyridine core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its reliable quality and consistent supply are critical for accelerating drug discovery and material science projects.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging the fluorine and bromine substituents for bioactivity.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-withdrawing sulfonyl group.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form new carbon-carbon bonds.
• Nucleophilic Aromatic Substitution: The fluorine atom at the 3-position is activated for substitution, allowing for further functionalization of the pyridine ring.
• Chemical Library Development: Employed in high-throughput and combinatorial chemistry for generating diverse compound libraries for biological screening.

Basic Information

Product Name	5-Bromo-3-Fluoro-2-(Methylsulfonyl)Pyridine
CAS No.	1446002-35-2
Molecular Formula	C7H5BrFNO2S
Molecular Weight	266.09 g/mol
Synonyms	2-(Methylsulfonyl)-5-bromo-3-fluoropyridine; 5-Bromo-3-fluoro-2-(methylsulfonyl)pyridine; 3-Fluoro-5-bromo-2-methylsulfonylpyridine; Pyridine, 5-bromo-3-fluoro-2-(methylsulfonyl)-; 1446002-35-2; 5-Br-3-F-2-MeSO2-Pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Fluoro-2-(Methylsulfonyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality supports compliance with the stringent requirements of cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.