Description

Methyl 7-Oxa-2-Azaspiro[3.5]Nonane-5-Carboxylate (Wx101539) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing seeking to develop new therapeutic candidates with improved properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing complex molecular architectures in drug discovery programs.
• Process Chemistry & Scale-Up: Serves as a critical raw material for the development and optimization of commercial-scale API manufacturing processes.
• Proteolysis Targeting Chimera (PROTAC) Development: Utilized in the construction of linkers and warhead components for targeted protein degradation therapies.
• Chemical Biology Probes: Incorporated into tool compounds for studying biological pathways and target engagement.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	Methyl 7-Oxa-2-Azaspiro[3.5]Nonane-5-Carboxylate (Wx101539)
CAS No.	1445951-80-3
Molecular Formula	C9H15NO3
Molecular Weight	185.22 g/mol
Synonyms	Methyl 7-oxa-2-azaspiro[3.5]nonane-5-carboxylate; 7-Oxa-2-azaspiro[3.5]nonane-5-carboxylic acid, methyl ester; WX-101539; Wx101539; WX101539; Methyl 2-azaspiro[3.5]nonane-5-carboxylate 7-oxide (related); Spirocyclic oxazolidinone ester intermediate
EINECS	Contact for details

Quality Control

Our Methyl 7-Oxa-2-Azaspiro[3.5]Nonane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.