Description

Racemic-(3R,5S)-tert-Butyl 3-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate (Wx101531) is a high-purity chiral spirocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral scaffold for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis to explore new chemical space and optimize lead compounds.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the development of scalable, cost-effective synthetic routes for active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, or insecticides with specific chiral activity.
• Ligand and Catalyst Preparation: Potential precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological studies in spirocycle formation and heterocyclic chemistry.

Basic Information

Product Name	Racemic-(3R,5S)-tert-Butyl 3-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate (Wx101531)
CAS No.	1445951-77-8
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate; (±)-(3R,5S)-tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate; 7-Boc-3-hydroxy-1-oxa-7-azaspiro[4.4]nonane; 1-Oxa-7-azaspiro[4.4]nonane-7-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3R,5S)-rel-; WX-101531; Wx101531; 1445951-77-8
EINECS	Contact for details

Quality Control

Every batch of Racemic-(3R,5S)-tert-Butyl 3-Hydroxy-1-Oxa-7-Azaspiro[4.4]Nonane-7-Carboxylate is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.