Description

2-Benzyl 8-tert-Butyl 3-(Hydroxymethyl)-2,8-Diazaspiro[4.5]Decane-2,8-Dicarboxylate is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceuticals, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas. Research and development teams in the pharmaceutical and biotechnology sectors require this high-purity intermediate to construct complex molecular architectures with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, especially those with spirocyclic or constrained peptide-mimetic structures.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization stages for constructing novel chemical libraries targeting GPCRs, kinases, and other biological targets.
• Chemical Biology Probe Development: Serves as a scaffold for creating tool compounds to study enzyme function and protein-protein interactions.
• Advanced Organic Synthesis: Employed in method development for constructing complex, three-dimensional heterocycles and spiro compounds.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Benzyl 8-tert-Butyl 3-(Hydroxymethyl)-2,8-Diazaspiro[4.5]Decane-2,8-Dicarboxylate
CAS No.	1445951-71-2
Molecular Formula	C22H32N2O5
Molecular Weight	404.50 g/mol
Synonyms	2,8-Diazaspiro[4.5]decane-2,8-dicarboxylic acid, 3-(hydroxymethyl)-, 2-benzyl 8-(1,1-dimethylethyl) ester; 2-Benzyl 8-tert-butyl 3-(hydroxymethyl)-2,8-diazaspiro[4.5]decane-2,8-dicarboxylate; tert-Butyl 3-(hydroxymethyl)-2-(phenylmethyl)-2,8-diazaspiro[4.5]decane-8-carboxylate; 2,8-Diazaspiro[4.5]decane-2,8-dicarboxylic acid, 3-(hydroxymethyl)-, 1-benzyl 5-tert-butyl ester; Spirocyclic diaza building block 1445951-71-2.
EINECS	Contact for details

Quality Control

Our 2-Benzyl 8-tert-Butyl 3-(Hydroxymethyl)-2,8-Diazaspiro[4.5]Decane-2,8-Dicarboxylate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.