Description

8-tert-Butyl 4-Ethyl 3-Oxo-2,8-Diazaspiro[4.5]Decane-4,8-Dicarboxylate CAS NO 1445951-68-7 is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic diaza scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers focused on developing next-generation therapeutics, particularly in areas requiring sophisticated heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions for clinical trial materials.

Basic Information

Item	Details
Product Name	8-tert-Butyl 4-Ethyl 3-Oxo-2,8-Diazaspiro[4.5]Decane-4,8-Dicarboxylate
CAS No.	1445951-68-7
Molecular Formula	C17H28N2O5
Molecular Weight	340.42 g/mol
Synonyms	8-tert-Butyl 4-ethyl 3-oxo-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate; tert-Butyl 4-ethyl 3-oxo-2,8-diazaspiro[4.5]decane-4,8-dicarboxylate; 2,8-Diazaspiro[4.5]decane-4,8-dicarboxylic acid, 3-oxo-, 4-ethyl 8-(1,1-dimethylethyl) ester; Spirocyclic diaza compound 1445951-68-7; 8-(tert-Butoxycarbonyl)-4-ethoxycarbonyl-3-oxo-2,8-diazaspiro[4.5]decane; Boc-protected diazaspirodecane derivative
EINECS	Contact for details

Quality Control

Our 8-tert-Butyl 4-Ethyl 3-Oxo-2,8-Diazaspiro[4.5]Decane-4,8-Dicarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.