Description

tert-Butyl 4-(Hydroxymethyl)-3-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and diazepane scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for developing new therapeutic agents, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads due to its spirocyclic structure.
• Kinase Inhibitor Synthesis: Employed in the construction of complex heterocyclic cores for potential kinase inhibitor candidates.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for scale-up and GMP production of clinical trial materials.

Basic Information

Product Name	tert-Butyl 4-(Hydroxymethyl)-3-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate
CAS No.	1445951-29-0
Molecular Formula	C14H24N2O4
Molecular Weight	284.35 g/mol
Synonyms	8-Boc-4-(hydroxymethyl)-2,8-diazaspiro[4.5]decan-3-one; tert-Butyl 4-(hydroxymethyl)-3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate; 2,8-Diazaspiro[4.5]decan-3-one, 4-(hydroxymethyl)-, 8-(1,1-dimethylethyl) ester; 8-Boc-2,8-diazaspiro[4.5]decan-3-one-4-methanol; 4-Hydroxymethyl-3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 1445951-29-0; Boc-protected diazaspirodecane derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Hydroxymethyl)-3-Oxo-2,8-Diazaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.