Description

tert-Butyl 5-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic indoline scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the generation of compound libraries for high-throughput screening.
• Spirocyclic Compound Synthesis: Exploited for constructing complex, three-dimensional molecular architectures that are prevalent in modern drug design to improve selectivity and metabolic stability.
• Chemical Biology Probes: Serves as a starting material for developing specialized probes to study biological pathways and protein functions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	tert-Butyl 5-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-carboxylate
CAS No.	1445951-09-6
Molecular Formula	C17H20BrNO3
Molecular Weight	366.25 g/mol
Synonyms	1-BOC-5-Bromo-2,3,5,6-tetrahydrospiro[indoline-3,4'-pyran]; tert-Butyl 5-bromo-1,2,5,6-tetrahydrospiro[indole-3,4'-pyran]-1-carboxylate; 5-Bromo-2,3,5,6-tetrahydrospiro[indoline-3,4'-pyran]-1-carboxylic acid tert-butyl ester; Boc-5-Bromo-tetrahydrospiro[indoline-3,4'-pyran]; Spiro[indoline-3,4'-pyran]-1-carboxylic acid, 5-bromo-2',3',5',6'-tetrahydro-, 1,1-dimethylethyl ester; 1445951-09-6; 5-Bromo-1-N-Boc-2,3,5,6-tetrahydrospiro[indoline-3,4'-pyran]
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 5-Bromo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediates, and specifications can be aligned with client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.