Description

tert-Butyl 9-(Hydroxymethyl)-8-Oxo-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and diaza scaffold. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. Research and development teams in the pharmaceutical and biotechnology sectors utilize this intermediate to streamline the synthesis of complex molecules, accelerating drug discovery and process development cycles.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead sections of PROTAC molecules due to its spirocyclic structure and functional handles.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve pharmacokinetic properties.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for potential APIs under Good Manufacturing Practice (GMP) guidelines.
• Bioconjugation & Chemical Biology: The hydroxymethyl and carboxylate protecting group offer sites for further functionalization, useful in creating probes or conjugate drugs.

Basic Information

Product Name	tert-Butyl 9-(Hydroxymethyl)-8-Oxo-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate
CAS No.	1445950-79-7
Molecular Formula	C14H24N2O4
Molecular Weight	284.35 g/mol
Synonyms	2,7-Diazaspiro[4.4]nonane-2-carboxylic acid, 9-(hydroxymethyl)-8-oxo-, 1,1-dimethylethyl ester; tert-Butyl 9-(hydroxymethyl)-8-oxo-2,7-diazaspiro[4.4]nonane-2-carboxylate; 1445950-79-7; 8-Oxo-9-hydroxymethyl-2,7-diazaspiro[4.4]nonane-2-carboxylic acid tert-butyl ester; Spirocyclic diaza intermediate; Boc-protected diazaspiro nonane derivative.
EINECS	Contact for details

Quality Control

Our tert-Butyl 9-(Hydroxymethyl)-8-Oxo-2,7-Diazaspiro[4.4]Nonane-2-Carboxylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch. We support development toward cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be sealed under an inert atmosphere after opening and desiccants are recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.