Description

tert-Butyl 4-benzyl-1-oxa-4,8-diazaspiro[5.5]undecane-8-carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with potential for improved efficacy and selectivity. It is primarily needed by research and development organizations in the pharmaceutical and biotechnology sectors, particularly those focused on central nervous system (CNS) therapeutics, oncology, and other areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The 1-oxa-4,8-diazaspiro[5.5]undecane core is relevant for developing inhibitors of various enzymes.
• Ligand Synthesis for Receptor Targeting: Employed in the creation of sophisticated ligands for G-protein-coupled receptors (GPCRs) and other biological targets.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of complex molecules.
• Academic & Contract Research: A valuable reagent for universities and CROs engaged in cutting-edge synthetic organic chemistry and drug discovery projects.

Basic Information

Product Name	tert-Butyl 4-benzyl-1-oxa-4,8-diazaspiro[5.5]undecane-8-carboxylate
CAS No.	1445950-77-5
Molecular Formula	C20H30N2O3
Molecular Weight	346.47 g/mol
Synonyms	8-Boc-4-benzyl-1-oxa-4,8-diazaspiro[5.5]undecane; 1-Oxa-4,8-diazaspiro[5.5]undecane-8-carboxylic acid, 4-(phenylmethyl)-, 1,1-dimethylethyl ester; 4-Benzyl-8-(tert-butoxycarbonyl)-1-oxa-4,8-diazaspiro[5.5]undecane; tert-Butyl 4-benzyl-1-oxa-4,8-diazaspiro[5.5]undecane-8-carboxylate; 1445950-77-5; 4-Benzyl-1-oxa-4,8-diazaspiro[5.5]undecane-8-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-benzyl-1-oxa-4,8-diazaspiro[5.5]undecane-8-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.