Description

(3R,5S,Z)-7-(4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethylsulfonamido)Pyrimidin-5-Yl)-3,5-Dihydroxyhept-6-Enoic Acid Calcium(Ii) CAS NO 1445208-17-2 is a high-purity, advanced pharmaceutical intermediate with a complex stereochemistry. This compound is critical for the synthesis of next-generation therapeutic agents, particularly in the statin and cardiovascular drug research pipeline. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in producing high-value active pharmaceutical ingredients (APIs). The material's defined stereochemistry ensures precise biological activity and is essential for developing targeted therapies.

Application

• Key Intermediate in Statin Analog Synthesis: Serves as a crucial building block for the research and development of novel HMG-CoA reductase inhibitors.
• Pharmaceutical R&D: Used in preclinical and clinical-stage drug development programs targeting hypercholesterolemia and cardiovascular diseases.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling up production for new chemical entities (NCEs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in API manufacturing.
• Academic & Institutional Research: Utilized in biochemical and pharmacological studies to investigate enzyme inhibition and metabolic pathways.
• Custom Synthesis: A starting material for the preparation of specialized derivatives and analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(3R,5S,Z)-7-(4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethylsulfonamido)Pyrimidin-5-Yl)-3,5-Dihydroxyhept-6-Enoic Acid Calcium(Ii)
CAS No.	1445208-17-2
Molecular Formula	C25H31CaFN3O6S
Molecular Weight	560.66 g/mol (Calcium salt)
Synonyms	Rosuvastatin Calcium Intermediate; (3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethanesulfonamido)pyrimidin-5-yl]-3,5-dihydroxy-(E)-6-heptenoic Acid Calcium Salt; ZD-4522 Calcium Salt Intermediate; Calcium (3R,5S,E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate; Rosuvastatin Calcium Key Intermediate; (E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt; (3R,5S)-Rosuvastatin Calcium Precursor
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity and chiral purity, NMR for structural confirmation, and Karl Fischer titration for water content. A detailed Certificate of Analysis (COA) is provided with each batch, documenting all critical quality attributes. We support our clients' regulatory filings with full analytical method information and stability data upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (3R,5S isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.