Description

2-Azaspiro[3.3]Heptane-2-Carboxylic Acid, 6-Formyl-, 1,1-Dimethylethyl Ester is a high-value, multifunctional spirocyclic building block designed for advanced organic synthesis. This compound is critical for medicinal chemistry research and development, offering a rigid, three-dimensional scaffold that is essential for modulating the physicochemical properties and biological activity of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex small molecules, particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Medicinal Chemistry Scaffold: Used to introduce conformational constraint into lead compounds, improving potency, selectivity, and metabolic stability during drug discovery.
• Peptidomimetic Synthesis: Serves as a proline or pipecolic acid analog in the design of novel peptide-like molecules with enhanced drug-like properties.
• Ligand Development: Employed in the creation of specialized ligands for catalysis and molecular recognition studies.
• Academic & Industrial Research: A valuable reagent for synthetic methodology development and exploring new chemical space in organic chemistry.

Basic Information

Product Name	2-Azaspiro[3.3]Heptane-2-Carboxylic Acid, 6-Formyl-, 1,1-Dimethylethyl Ester
CAS No.	1440960-67-7
Molecular Formula	C12H19NO3
Molecular Weight	225.28 g/mol
Synonyms	tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate; 2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-formyl-, 1,1-dimethylethyl ester; 6-Formyl-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; Boc-2-aza-6-formylspiro[3.3]heptane; (6-Formyl-2-azaspiro[3.3]heptan-2-yl)carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 2-Azaspiro[3.3]Heptane-2-Carboxylic Acid, 6-Formyl-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to light and oxidation, prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.