Description

6-(2,2,2-Trifluoroethoxy)Pyrimidine-4-Carboxylic Acid is a high-value trifluoroethoxy-functionalized pyrimidine derivative, serving as a critical synthetic intermediate for advanced pharmaceutical and agrochemical research. Its core value lies in enabling the development of novel active ingredients with enhanced metabolic stability and bioavailability. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoroethoxy group can impart favorable biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysts for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or polymers with specific electronic properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional laboratories for methodological studies in heterocyclic and fluorine chemistry.

Basic Information

Item	Detail
Product Name	6-(2,2,2-Trifluoroethoxy)Pyrimidine-4-Carboxylic Acid
CAS No.	1439896-74-8
Molecular Formula	C7H5F3N2O3
Molecular Weight	222.12 g/mol
Synonyms	6-(2,2,2-Trifluoroethoxy)-4-pyrimidinecarboxylic acid; 4-Pyrimidinecarboxylic acid, 6-(2,2,2-trifluoroethoxy)-; 6-(Trifluoroethoxy)pyrimidine-4-carboxylic acid; 6-(2,2,2-Trifluoroethoxy)pyrimidine-4-carboxylic acid; 1439896-74-8; 6-(2,2,2-Trifluoroethoxy)-4-carboxypyrimidine; 6-(Trifluoroethoxy)-4-pyrimidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 6-(2,2,2-Trifluoroethoxy)Pyrimidine-4-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.