Description

Methyl 6-Bromo-2-Fluoro-3-Methylbenzoate is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. Its value lies in its multifunctional structure, which incorporates bromo, fluoro, and ester groups, enabling precise molecular modifications. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the construction of complex active molecules, particularly in lead optimization and discovery phases.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic display materials and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create biaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.
• Fluorine Chemistry Studies: Acts as a model compound for studying the influence of fluorine atoms on the reactivity and physical properties of benzoate esters.

Basic Information

Product Name	Methyl 6-Bromo-2-Fluoro-3-Methylbenzoate
CAS No.	1437780-03-4
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	6-Bromo-2-fluoro-3-methylbenzoic acid methyl ester; Methyl 6-bromo-2-fluoro-m-toluate; 2-Fluoro-6-bromo-3-methylbenzoic acid methyl ester; Benzoic acid, 6-bromo-2-fluoro-3-methyl-, methyl ester; Methyl 2-fluoro-6-bromo-3-methylbenzoate; 3-Methyl-6-bromo-2-fluorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 6-Bromo-2-Fluoro-3-Methylbenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable performance in your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.